Diabetic cardiomyopathy

Diabetic cardiomyopathy

Diabetic cardiomyopathy.

I t has been over 30 years since Rubler et al. (1) described four diabetic patients with congestive heart failure (CHF), normal coronary arteries, and no other etiologies for CHF and proposed that it was due to diabetic cardiomyopathy. Eight years ago, I reviewed the evidence for diabetic cardiomyopathy as a unique entity unassociated with coronary artery disease and concluded that diabetic car...

Diabetic cardiomyopathy

Diabetic cardiomyopathy is a distinct primary disease process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Epidemiological and clinical trial data have confirmed the greater incidence and prevalence of heart failure in diabetes. Novel echocardiographic and MR (magnetic resonance) techniques have enabled a more accurate means of phenotyping diabetic...

Diabetic Cardiomyopathy and Adiponectin

People with DM can develop heart dysfunction called diabetic cardiomyopathy [5]. This is characterized by dilation and hypertrophy of the myocardium, accompanied by systolic dysfunction and / or left ventricular diastolic and their presence is independent of ischemic heart disease or hypertension coexistence [7]. Although diabetic cardiomyopathy is a chronic subclinical condition [8], eventuall...

Proxisome prolifrator-activated receptors alpha and delta in diabetic cardiomyopathy

Peraxisome prolifrator-activated receptors (PPARs) are a group of nuclear receptors comprising three isoforms termed alpha, beta/delta and gamma. PPARs can modulate metabolic processes especially fatty acid (FA) metabolisms via exerting transcriptional control on activating genes involved in fuel utilization. Thus, they can exert positive role in controlling chronic diseases such as diabetes. A...